collafleece® is produced in a certified process from the porcine dermis. The unique manufacturing process provides a safe and cell-free product that is regulated according to the EC guidelines. Its natural hemostatic effect and the fast resorption making collafleece® an excellent medical device for the treatment of oral wounds.

Damage to the blood vessel wall leads to subendothelial collagen release. The collagen directly or indirectly interacts with the surface receptors on thrombocytes. The binding of collagen initiates a reaction cascade leading to transformation and aggregation of the thrombocytes. Additionally, the thrombocytes are cross-linked by fibrinogen. The resulting (white) thrombus initially stabilizes the wound. Accordingly, collagen membranes and sponges support the formation of a blood coagulum and contribute to a rapid stabilization of the wound area. Due to their hemostatic effect, collagen sponges and cones can be used for stabilization of biopsy harvesting sites or covering of minor oral wounds and extraction sockets, respectively.

Medication with anticoagulant drugs (i.e. heparin or warfarin) poses a risk for patients of bleeding following tooth extraction. Local hemostatic agents like collagen fleeces can prevent postoperative bleeding without the need to pause the anticoagulant therapy. A retrospective study with 200 anticoagulated patients showed a very low rate of bleedings following application of collagen sponges with a similar composition (collacone®).

A dry application of collafleece® is recommended because pre-hydration may impair its hemostatic properties. At the defect site, the fleece soaks up blood very quickly but maintains its integrity. A direct fixation by sutures/pins is not possible, but also not necessary. Indirect fixation, on the other hand, by cross- or holding sutures could help keeping the fleece in place e.g. in extraction sockets or at soft tissue harvesting sites.

collafleece® is a cost-effective alternative to barrier membranes during sinus floor elevations for the protection of the Schneiderian membrane. It can also be used to protect barrier membranes from fast bacterial resorption when an exposure is likely.