Bone graft materials are applied to replace and regenerate bone matrix lost by various reasons such as tooth extraction, cystectomy or bone atrophy following loss of teeth or inflammatory processes. For the filling of bone defects, the patient‘s own (autologous) bone is considered the „gold standard“, because of its biological activity due to vital cells and growth factors. Nevertheless, the harvesting of autologous bone requires a second surgical site associated with an additional bony defect and potential donor site morbidity.

In addition, the quantity of autologous bone is limited. Today, due to a constant development bone graft materials provide a reliable and safe alternative to autologous bone grafts. Clinicians can choose between a variety of different bone graft materials and augmentation techniques.

ALLOPLASTIC
SYNTHETICALLY PRODUCED (CALCIUM PHOPSHATE CERAMICS)

maxresorb^®

maxresorb^® inject

collacone® max

maxresorb^® is an innovative, safe, reliable, and fully synthetic bone substitute material that is characterized by controlled resorption properties and outstanding handling characteristics.

maxresorb® is composed of 60% slowly resorbing hydroxyapatite (HA) and 40% fast resorbing beta-tricalcium phosphate (β-TCP) [1,2]. The unique synthesis-based production process ensures a completely homogenous distribution of both mineral phases. The peculiar composition of maxresorb® promotes fast formation of new vital bone, while ensuring a long-term mechanical and volume stability.

The osteoconductivity of maxresorb® is based on a matrix of interconnecting pores, a very high overall porosity of approx. 80% as well as its rough surface. The nano-structured surface facilitates the adsorption of blood, proteins, and stem cells and promotes cell differentiation and osseous integration. maxresorb® is thus an ideal scaffold for the migration of bone forming cells and binding of signaling molecules, which can accelerate tissue integration and regeneration [3].

maxresorb® offers a reliable alternative to bovine bone in a variety of indications.

IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY

• Sinus lift
• Ridge augmentation
• Intraosseous defects
• Extraction sockets
• Osseous defects
• Furcation defects

• 60% HA/40% β-TCP
• Osteoconductive
• Ultra-high interconnected porosity
• Volume and mechanical graft stability
• Safe, reliable and sterile
• Very rough and hydrophilic surface
• 100% synthetic and resorbable

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maxresorb^® inject is a unique four-phasic injectable bone graft paste with controlled resorption properties. The water-based gel contains active HA nanoparticles mixed together with small maxresorb granules particles (60% HA/40% β-TCP). The HA nanoparticles (size 15–50 nm) provide an extensive surface area for cellular interactions, which lead to rapid resorption, thereby promoting new bone formation. In addition, the maxresorb^® granules contained in the gel help maintain the volume over time.

Owing to its specific composition, the viscous properties of maxresorb^® inject allow perfect shaping, molding, fitting and complete bonding to the surrounding bone surface of the defect. maxresorb^® inject is a non-hardening and ready-to-use bone paste. The syringe design allows direct and easy application to the defect site. Once applied, maxresorb^® inject is gradually replaced by new bone.

maxresorb^®  inject is designed for the regeneration of smaller defects that do not require extra volume stability. In these cases, the particular composition of maxresorb^® inject and its active HA nanoparticles offer an extensive surface area that promotes cell-biomaterial interactions, thus leading to a rapid cellular resorption of the particles and accelerating the formation of new bone.

IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY

• Sinus lift
• Intraosseous defects
• Socket preservation
• Osseous defects
• Regeneration in small/contained defects
• Gap-filling in combination with other bone substitutes

• Synthetic, resorbable and safe
• Ready to use/easy handling
• Viscous and moldable
• Non-hardening
• Optimal adaptation to surface contours
• Active HA nanoparticles
• Contains 60% HA/40% β-TCP

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collacone® max is a flexible composite cone composed of synthetic granules and porcine collagen fibres. The collagen facilitates the handling of the graft particles, while the consistency of the material readily allows it to shape to the socket walls or defect. collacone® max is designed to fit into the void of the extraction socket and does not require rehydration before application. The cone may be applied both as a protective medium and temporary void filler in the extraction socket when performing an early implantation, or as a regenerative material that assists new bone formation in the case of delayed implantation. Following application the cone is slowly resorbed and replaced by new bone.

collacone® max is a biomimetic composite material that resembles the physical and chemical properties of the mineralized human bone matrix in its composition of collagen and biphasic calcium phosphate. The collagenous phase holds the particles in place and provides biological signals that promote wound healing within the socket. Furthermore, the natural hemostatic effect of collagen helps to control bleeding. The biphasic calcium phosphate granules comprised of 60% hydroxyapatite and 40% β-tricalcium phosphate, ensure volume stability and complete resorption at a controlled rate. collacone® max maintains the socket space and provides a scaffold for bone ingrowth and new bone tissue formation. Following application the cone is slowly resorbed and replaced by new bone.

collacone® max is designed for application in extraction sockets. It may be applied both as a protective medium and temporary void filler when performing an early implantation, or as a regenerative material that assists new bone formation in the case of delayed implantation (socket preservation). Furthermore, it can be applied in the regeneration of bony defects as a scaffold to support the ingrowth of adjacent vital bone.

IMPLANTOLOGY, PERIODONTOLOGY AND ORAL AND CMF SURGERY

• Socket preservation
• Ridge preservation
• Intraosseous defects
• Peri-implant defects
• Defects after root resection, apicoectomy and cystectomy

• Form-fitted cone shape for an easy application
• Adapts to the defect contours
• Maintains space and avoids soft tissue collapse
• Reduces the need for subsequent augmentative procedures
• Improves the aesthetic outcome of the final prosthesis

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