L-PRF™ is a 3-D autogenous combination of Platelet Rich Fibrin derived from the patient’s blood¹. A simplified chairside procedure results in the production of a thin, compressed layer of platelet rich fibrin that is strong, pliable and suitable for suturing. This natural fibrin network is rich in platelets, growth factors and cytokines that are derived from the blood platelets and leukocytes¹.

The presence of these proteins have been reported to produce rapid healing, especially during the critical first seven days after placement². This network promotes more efficient cell migration and proliferation without chemical or bovine thrombin additives³.

– Simple and economic4
– Natural – 100% autologous4
– Thin Fibrin Matrix & Plugs4
– Leukocytes, Platelets and Fibrin1
– Slow Release at ≥ 7 days1
– Matrix for Bone Graft Material5

No Anticoagulant
No Bovine Thrombin
No Heating
No Pipetting
No Second Spin
No Chemical Additives
No Expensive Consumables

Clinically, Leukocyte-Platelet Rich Fibrin displays excellent working properties. This biomaterial is resilient, strong and pliable, making it easy to manipulate. It can be cut to size, and is supple enough to adapt to many anatomical areas. It is adhesive in nature and very receptive to suturing. In addition, there is ample working time since L-PRF™ is stable at room temperature for several hours4.

The IntraSpin™ System establishes a three-step protocol for drawing and centrifuging the patient’s blood, removing the fibrin clot and processing it in the Xpression™ Fabrication Kit. A thin, compressed layer of Platelet Rich Fibrin or plugs for extraction sites can then be formed, using either the internal plate or the piston assembly.

L-PRF™ matrix acts as a carrier for particulate bone material⁴. When incorporated, the graft material is suspended in the fibrin matrix and handling characteristics are dramatically improved.

IntraSpin™ System is intended to be used for the safe and rapid preparation of autologus Platelet Rich Fibrin (PRF) from a small sample of blood taken at the patient’s point of care. The PRF can be mixed with autograft and/or allograft bone prior to application to a bony defect for improving handling characteristics. It requires only one centrifugation without pipetting, mixing, heating or additives. Every component of the IntraSpin™ System has been specifically selected and engineered to act in concert as a graft delivery. IntraSpin™ System components have been FDA cleared and are optimized to ensure proper material biocompatibility and clinical performance.

A simple three-step processing protocol necessitates drawing blood, spinning blood and expressing the fibrin clot in the Xpression™ Fabrication Kit. The system is comprised of three product groups specifically designed for completing this processing protocol.

The Blood Sample Collection Set and materials have been selected for proper biocompatibilty, collection and maintenance of the blood sample.

The IntraSpin™ Centrifuge has a specific configuration and set of dynamic parameters. It has been calibrated and tested to ensure separation of the blood into proper segments and consistencies for Platelet Rich Fibrin.

The Tissue Regeneration Kit includes the Xpression™ Fabrication Kit which is engineered to optimize the final step in the fabrication of Platelet Rich Fibrin. The weighted press is designed to express serum from the fibrin clot in a controlled manner and to form thin compressed layer of Platelet Rich Fibrin of a consistent thickness. A piston and cylinder assembly is used for the creation of Platelet Rich Fibrin plugs. The kit and instrumentation is also designed to aid incorporating graft material within the Platelet Rich Fibrin matrix.

Dental/Oral and Maxillofacial Surgical Sitesen

L-PRF™ improves wound healing after dental and maxillofacial surgeries7. The application of L-PRF™ is recommended in combination with all botiss soft and hard tissue regeneration materials, e.g. in

– Sinus floor elevation4
– Extraction sockets 1,4,5,6
– Augmentation procedures5

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1 Dohan Ehrenfest DM, Del Corso M, Diss A, et al. Three-dimensional architecture and cell composition of a Choukroun’s platelet-rich fibrin clot and membrane. J Periodontol. 2010 Apr;81(4):546-55.
2 Dohan Ehrenfest, David M.; de Peppo, Giuseppe; Doglioli Pierre; Sammartino Gilberto. Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. Volume 27, Number 1, February 2009, pp. 63-69(7)
3 Dohan DM,, Diss A, Dohan SL, Dohan AJ, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endo. 2006 Mar;101(3):e51-5.
4 Michael Toffler, Nicholas Toscano, Dan Holtzclaw, DDS, et al.Introducing Choukroun’s Platelet Rich Fibrin (PRF) to the Reconstructive Surgery Milieu. J Implant & Adv Clin Dent. 2009 Sept; 1(6): 21-32.
5 Simonpieri A, Del Corso M, Vervelle A, Jimbo R, et al. Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 2: Bone graft, implant and reconstructive surgery. Curr Pharm Biotechnol 2012 Jun;13(7):1231-56.
6 Del Corso M, Mazor Z, Rutkowski JL, et al. The use of leukocyte- and platelet-rich fibrin during immediate postextractive implantation and loading for the esthetic replacement of a fractured maxillary central incisor. J Oral Impl 2012 Apr;38(2):181-7.
7 Jain V, Triveni MG, Kumar AB, Mehta DS. Role of platelet-rich-fibrin in enhancing palatal wound healing after free graft. Contemp Clin Dent. 2012 Sep;3(Suppl 2):S240-3.
8 Soadoun AP, Touati B. Soft tissue recession around implants: Is it still unavoidable? –Part II. Pract Proced Aesthet Dent. 2007 Mar;19(2):81-7.