cerabone^® plus is the only available bovine bone substitute material containing hyaluronate. It is a combination of cerabone^® granules (available with small or large granules) and sodium hyaluronate, which is a water-soluble form of hyaluronic acid. The cerabone^® granules are delivered with hyaluronate in a blister for convenient hydration.

Hyaluronic acid is a large organic polymer (polysaccharide) widely distributed throughout the human body as one major component of the extracellular matrix of many tissues such as skin, muscles, tendon, periodontal soft tissues and alveolar bone. Hyaluronic acid has structural and space-occupying functions and plays a major role in the body’s tissue repair processes^1,2.

For the production of the recombinant sodium hyaluronate used in cerabone^® plus state-of-the-art biotechnological fermentation processes are employed.

Due to its polymeric structure with many exposed reactive hydroxyl groups, hyaluronic acid forms covalent hydrogen bonds with water molecules in aqueous solutions. This way hyaluronic acid is able to retain huge amounts of liquids to form a hydrogel with high viscosity. It is estimated that the molecule can incorporate a volume of liquid that is 1000 times larger than the molecule itself.

cerabone^® plus possesses all properties of the cerabone^® granules, which are maximum safety (due to unique 1200°C manufacturing process), exceptional purity (100% pure bone mineral), human-like bone structure (rough surface, interconnected porosity) and long-term volume stability.

The cerabone^® granules in cerabone^® plus provide an osteoconductive scaffold for bone forming cells promoting osseous regeneration. As the cerabone^® granules are only superficially resorbed, they provide long-term volume stability of the grafted site. The hyaluronic acid in cerabone^® plus is completely resorbed by enzymatic degradation within the first weeks following implantation³.