Biofunctionalization through Hyaluronic acid

Exceptional liquid binding capacity
Produced naturally in the body
Immunomodulatory activities1
Proliferation of fibroblasts2
Collagen production3 

Promotes blood vessel formation and early soft tissue healing 4,5

For more details refer to Catalogue or Product page.

cerabone® plus

cerabone® plus combines the established bovine bone grafting materialcerabone® with the well-known properties of hyaluronic acid.

Thanks to the pronounced liquid binding capacities of hyaluronate, cerabone® plus forms a sticky bone material upon hydration that provides unique application comfort by allowing both easy uptake and delivery to the site of application.



State-of-the-art biotechnological fermentation processes are employed for the production of the recombinant sodium hyaluronate used in cerabone® plus.

Properties + Benefits

Osteoconductivity and volume stability of cerabone®plus proven properties of hyaluronate

  • Sticky and malleable following hydration
  • Efficient defect filling and time-saving application
  • Easy defect contouring
  • Minimized displacement of single granules during application


approx. 0.5 ml saline solution per 1.0 ml cerabone® plus

cerabone® plus requires hydration before use which can conveniently be performed in the provided blister.

Optimal consistency can be tailored to the specific needs by adjustment of liquid volume. E.g. adding slightly less liquid results in a more stable consistency, while adding more liquid enables better dispersion.


Implantology, Periodontology, Oral and CMF Surgery

  • Horizontal and vertical augmentation
  • Peri-implant defects
  • Periodontal intrabony defects
  • Socket and ridge preservation
  • Sinus lift
  • Furcation defects (class I and II)


If the product appears dry following hydration and no connected mass has formed, additional saline solution can be added dropwise and mixed with the product until the desired texture is obtained. On the other hand, insufficient or excessive amount of liquid can result in a failure to form the described texture or a loss thereof. Likewise, excessive liquid at the augmentation site, i.e. in case of profuse bleeding in sinus floor- or socket augmentation, may reduce the handling of the bone graft during application and its adaptation to the defect. Intra-operatively, cerabone® plus performs optimally when bleeding at the defect site can be controlled, as in the case of well visible defects, e.g. in lateral augmentation.


cerabone® plus*

Art.-No. cerabone® Particle Size Content
1810** 0.5 – 1.0 mm 1 x 0.5 ml
1811 0.5 – 1.0 mm 1 x 1.0 ml
1820** 1.0 – 2.0 mm 1 x 0.5 ml
1821 1.0 – 2.0 mm 1 x 1.0 ml

* Please contact your local distributor to check for availability.
** coming soon


Handling Tips

  • Add liquid carefully dropwise if it is not possible to measure the volume for hydration
  • Remove excess liquid from the defect site prior to the application
  • Preferably use in self-containing defects
  • Fixate the graft with a barrier membrane
For more details refer to Catalogue or Product page.